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Additionally, the newly synthesized compounds significantly reduced LPS-induced production of ROS and pro-inflammatory cytokines (IL-6, TNF-, and NO) in RAW 264.7 macrophages

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Patients should receive clear written and verbal information about: Expected side effects of each medication Warning signs requiring immediate medical attention (severe abdominal pain, persistent vomiting, signs of pancreatitis, mood changes, suicidal thoughts) The importance of adherence to prescribed doses Lifestyle modifications to support treatment goals Multidisciplinary coordination may be beneficial, particularly when care involves both smoking cessation services and weight management clinics

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Sharpe LJ, Luu W, Brown AJ

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