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Treatment duration varies based on individual weight loss goals and physiological response

A retrospective analysis of 461,382 adults treated with GLP-1 receptor agonists found that nutritional deficiencies were diagnosed in 12.7% of patients within six months and 22.4% within twelve months, with vitamin D deficiency the most common at roughly 13.6% by the one-year mark

Given the appetite-suppressing effects of GLP-1 RAs, the MEAL approach emphasises maintaining energy balance through frequent small meals and nutrient-dense snacks such as fruit, yogurt, or nuts

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The mechanism story is broad, but most of it is built on cell and animal models