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The authors propose that the alternate version of GLP1R gene creates a protein that is functionally the same, but is moved more efficiently through the cell to the surface, where it can be targeted by the drug

Consequently, this vast expression of GLP-1R has enabled researchers and clinicians to explore potential therapeutic uses of GLP-1RAs in neurologic systems and their implications in sub-neurologic systems, principally the neuro-ophthalmic system

Although semaglutide and tirzepatide are GLP-1 agonists, tirzepatide generally works better for weight loss and obesity

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Led by researchers at University College London (UCL), University College London Hospitals and Homerton University Hospital, the BARI-STEP trial evaluated the efficacy and safety of semaglutide 2.4 mg once weekly in patients who had undergone Roux-en-Y gastric bypass or sleeve gastrectomy at least one year previously but had lost less than 20% of their body weight after surgery