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So this is my personal opinion, but you will always have segments of the population that are resistant to using pharmaceuticals or want to try natural solutions first, so products like berberine arent going to go away. As for gut health, which has attracted more awareness as GLP-1 drugs have gained traction, SPINS data show sales of probiotic supplements were down 7.6% in the year to October 6

doi: 10.3390/nu15143194 45

doi: 10.1002/bip.10257

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If you often drink alcohol or do intense exercise 24 hours before your treatment, this could possibly happen