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Recently, hesperetin has gained attention for its potential anti-COVID-19 activity, with several studies suggesting that it could be used not only as an anti-COVID-19 agent but also as a preventative measure against cancer by inhibiting key signaling pathways, particularly COX-2 inhibition

Here we review the NICE guidelines, with a specific focus on their implications for PA, and highlight s areas for improvement in addressing the needs of such individuals

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