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It has a synergistic effect with other antioxidants like vitamin E, enabling the body to defend against cancers like prostate and colon cancer

10.1007/s11064-016-1837-9 [DOI] [PubMed] [Google Scholar] Rae C

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Melatonin alleviates chilling stress in cucumber seedlings by up-regulation of CsZat12 and modulation of polyamine and abscisic acid metabolism

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In a randomized, double-blind, placebo-controlled trial in 52 patients with systolic heart failure, 300 mg/day of supplemental thiamin for one month did not improve LVEF compared to placebo (82)