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Diabetes Metab J, 45

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Although the actions of GLP-1 on the beta-cell are preserved yet modestly diminished in T2DM, the diabetic alpha-cell retains near normal responsivity to low dose GLP-1 infusion, with inhibition of glucagon secretion seen to a similar extent in diabetic vs

Substantial invested capital will be necessary to understand whether these novel targets and modalities will be successful in treating obesity