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Questions remaining include optimal human dosing, long-term safety, effects across different populations, interactions with diet and exercise, and whether benefits extend beyond weight loss to improvements in cardiometabolic disease outcomes

These represent realistic best-case scenarios, modest but meaningful improvements or preservation

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Its ability to influence gene expressionreportedly altering the activity of thousands of genesprovides a powerful model for investigating how cellular function can be modulated towards a regenerative state

15 , eadd1951 (2023)

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