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Perturbations of ER function cause ER stress leading to the unfolded protein response, which includes inhibition of protein synthesis, protein refolding, and clearance of misfolded proteins [75]

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D-Retro-Inverso (DRI) modification addresses this by: using D-amino acids (mirror images of natural L-amino acids) and reversing the sequence

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Garner mentioned that, Its primarily marketed for obesity management rather than weight loss. [3] In December 2024, the FDA approved Zepbound (tirzepatide) as the first and only prescription medicine for moderate-to-severe obstructive sleep apnea in adults with obesity