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In STZ-treatment rats, Exendin-4 improved learning and memory performance, protected hippocampal neurons against degeneration, and reversed STZ-induced tau hyperphosphorylation through downregulation of GSK-3 activity (154, 155, 182)

10.1016/j.cell.2013.12.021 53 ColmanE.GoldenJ.RobertsM.EganA.WeaverJ.RosebraughC

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The mechanisms of action inherent to these inhibitors have been thoroughly explored, drawing upon insights derived from preclinical investigations