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This dysregulation is secondary to mutations in elements of the pathway that include the APC gene (adenomatous polyposis coli), -catenin, or other elements, which make the pathway to be constitutively active and has oncogenic consequences [118, 119]

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In 2015, another double-blind RCT reported significant improvements in pain associated with aphthous ulcers with a B12 ointment compared with a B12-free ointment

The heterogeneity between studies is not surprising given the number of potential confounding variables

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Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels