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Inherited mutations in the -glutamyl carboxylase (GGCX) gene are the cause of VKCFD type I and mutations in the vitamin K epoxide reductase (VKORC1) gene are the cause of VKCFD type II

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For further biological evaluation, co-culture systems and reconstructed skin models should be adopted to screen for the ability of the novel compounds to interfere with the melanogenesis process, especially following stimuli including UV irradiation, exposure to a-MSH or proinflammatory cytokines

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It is not, however, a cure-all and like any treatment, it should be considered with the guidance of medical professionals