The key distinction is CNS access: intranasal supply leverages olfactory and trigeminal nerve transport to deliver NAD+ directly to brain tissue, making it very valuable for brain safety and cognitive research protocols
Firstly, the impact is partly due to ameliorating caspase-3 and Bax activity and upregulating Bcl-2 [156]
Safety and Toxicology: Comprehensive toxicology studies to evaluate acute and chronic effects, including cardiovascular, renal, and pancreatic safety profiles
Retatrutide is a triple-receptor agonist that targets GIP, GLP-1, and glucagon receptors, making it a particularly powerful option for weight management and metabolic health
Research shows that Ozempic does fairly well, and most side effects are mild and temporary
So the abdomen wins on paper, but rotating between all three sites is better for your tissue long-term than staying fixed to one location