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The primary function of the HSD11B1 encoded enzyme is to reduce the 11-oxo groups in cortisone and 11-dehydrocorticosterone to the active glucocorticoids, cortisol and corticosterone, respectively

After administering BPC 157 to rats with a ligated inferior caval vein, the beneficial effects induced by BPC 157 were complemented with altered Egr, Nos, Srf, Vegr , and Kras gene expression

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References Goldstein AL, Hannappel E, Sosne G, Kleinman HK

While no clinical trials have examined BPC-157 for hip conditions directly, extensive preclinical work on tendons, ligaments, and muscles provides strong mechanistic support for its application to hip problems