Editing efficiency was determined on bulk-edited cell populations by targeted PCR of the Cas9-targeted region and secondary PCR using overhang sequences (Table S1), followed by Illumina MiSeq, as previously described (Aubrey et al, 2015)
Xeomin (or incobotulinumtoxina) is a type of botulinum toxin type A
Coffin et al., in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., 2008
As the skin ages, the ECM gradually degrades and deteriorates, leading to noticeable changes in skin function and appearance [41, 42]
The mice bearing the MC38-hPD-L1 tumor model were acclimated at 25 C and 55% of humidity under natural light/dark conditions, with standard mice chow and water available ad libitum
Irrespective of ethical concerns regarding the justifiability of animal experiments in research activities, animal experimentation may not align with precision medicine approaches, which focus on the genetic diversity of human populations and inter-individual differences based on non-hereditary alterations during the life course (29, 30)
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