2002;8(11):BR439-443
In our experimental condition, HC treatment determined a downregulation of NPC1, a lysosomal cholesterol transporter that facilitates the efflux of cholesterol from the lysosome to the cytoplasm
The concept that an increase in the LBP may increase ligand promiscuity was further supported by biochemical studies in which threonine was replaced by the larger amino acid aspartic acid, which prevented androgen binding, presumably by steric hindrance, making the mutant receptor unresponsive to androgen activation 166
C.BuscheT.KalinowskiJ.BourdeauxF.GriningerM.et al (2018)
However, alternative oxygen concentrations, such as 1% or 5%, were not investigated, leaving it unclear whether the effects observed are specific to the 3% condition or indicative of a more general hypoxia-dependent response
In addition, probiotics produce various antioxidant metabolites, such as GSH and folate