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doi: 10.3389/fendo.2014.00056 Received 20 March 2014 Accepted 07 April 2014 Published 22 April 2014 Volume 5 - 2014 Edited by Rosaria Meccariello, University of Naples Parthenope, Italy Reviewed by Rosanna Chianese, Second University of Naples, Italy

Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

Research shows improvements in exercise capacity, especially for cardio or high-intensity workouts

The level of specificity must be determined for each assay

Leeds IL, Holubar SD, Hull TL et al

The research on this remains mostly anecdotal, but some clinical evidence is emerging