By optimizing 3 FUNCTIONS , GLP-1s ensure that you have more than just a temporary solution
Learning how to rotate injection sites and keeping track of symptoms can go a long way in making things more comfortable
5 years of Farxiga usage: Weight loss: 5-8 pounds (maximum amount achievable) Total costs: $30,000 to $36,000 (self-pay) or $1,500 to $6,000 (with insurance coverage) Side effects: Permanent UTIs, recurring yeast infections, increased dehydration risk Outcome after discontinuation: Weight gain back within 3 to 6 months Elimination of diabetes: 0% only possible through managing symptoms Frequency: Every day for years (and potentially a lifetime) Bariatric surgery (one-time surgical procedure): Weight loss: 60-80% of excess body weight Total costs: $15,000 to $25,000 (self-pay), or insurance coverage is often available Side effects: Recovery period post-surgery (2-4 weeks) Long-term outcome: Physiological change
The resulting conjugate molecule activates a whopping five receptors on the cell surface and in the nucleusand in mice, it appears to offer a potent, safe treatment for obesity and diabetes ( Nature 2026, DOI: 10.1038/s41586-026-10427-5)
Iwamoto E, Ho I, Way EL
Examples include insulin, growth hormone, and oxytocin
