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GLP-1 receptor agonists enhance glucose-dependent insulin secretion from pancreatic beta cells while suppressing inappropriate glucagon release, thereby improving glycemic control
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At 12 months, semaglutide reaches 13 to 16% while tirzepatide reaches 18 to 23%
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Trials have demonstrated that the latest basal analogues may cause less hypoglycaemia than first-generation basal analogues and NPH insulin, while rapid-acting analogues achieve better mealtime coverage and less post-meal hypoglycaemia than short-acting (regular) human insulin [87, 88]
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