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Enforced pgc-1alpha expression promotes Cd8 T cell fitness, memory formation and antitumor immunity

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The combination therapy of SAHA (40 mg/kg, intraperitoneal injection every 3 days) and B7x neutralizing antibody (200 g/mouse, intraperitoneal injection every 2 days) significantly delayed tumor growth, with a tumor inhibition rate of 80.6%, and significantly increased the infiltration of CD8 + and CD4 + T cells in the tumor microenvironment (67)

It helps to detoxify the body by binding to toxins and making them easier to eliminate