In order to monitor the intracellular translocation of agonists, as well as GLP-1Rs, we used fluorescently labeled exendin-4, exendin-phe1, and exendin-asp3 conjugates, with fluorescein isothiocyanate (FITC) at position K12, which we previously found useful for labeling GLP-1R 28
Physical Protection: Store vials upright to prevent leaks and avoid stacking them
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW
Non-fluorescent hemocytes, and hemocytes expressing/stained with each fluorophore individually were used to calculate the color compensation values and to determine the level of autofluorescence of the hemocytes
many people find these effects manageable and temporary
The growing clinical trial data in Phase III showing efficacy of dual GLP-1/amylin co-activation over current GLP-1 monotherapy are a game-changer for the market, delivering the clinical evidence required to support FDA regulatory approval, positive payer coverage decisions, and physician adoption in the increasingly competitive diabetes and obesity treatment landscape