Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucosedependent insulinotropic polypeptide
10.1056/NEJMoa2301972 [DOI] [PubMed] [Google Scholar] 51
By engaging all three receptors simultaneously, retatrutide aims to suppress appetite, regulate blood sugar levels and increase the body's metabolic rate and help increase energy expenditure and influence fat metabolism, though the exact contribution of each pathway is still being studied
Prior Presentation: This work was presented in part at the 2025 International Society for Pharmacoepidemiology (ISPE) Annual Meeting held 2226 August in Washington, DC, USA
Elevated levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) are commonly found in Hashimoto's patients
Investigated for energy expenditure and thermogenic activity