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NAD + homeostasis is not only regulated at the systemic level, but the pathways involved in synthesis and consumption also present dynamic and complex cellular locations and regulation

Treatment usually begins with a lower dose that gradually increases over weeks (dose titration) to improve tolerability

Important Considerations Consultation Required : This treatment may not be suitable for pregnant or nursing women, individuals with vitamin allergies, or those with cardiovascular conditions

It should not be assumed to be the best longevity or detoxification option simply because it enters the bloodstream directly

doi:10.2337/db22-823-P