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The activity of ribosomal genes was evaluated through multiple cytogenetic indicators: the frequency of acrocentric chromosome associations, the number of nucleolar organizer regions (NORs) in these acrocentric chromosomes, and the intensity of silver staining (Ag-NOR staining)

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It has been demonstrated that the amyloid precursor protein-derived C-terminal fragment (APP-CTF) may act as a trigger for AD pathology, with its overaccumulation resulting in impaired mitochondrial structure and defective mitophagy