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For any particular estrogen/progestogen combination, the dosage regimen prescribed should be one which contains the least amount of estrogen and progestogen that is compatible with a low failure rate and the needs of the individual patient

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These drugs are clinically effectivebut far from cost-effective

In heart failure, energy production is impaired due to altered mitochondrial function and increased glycolysis

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This regeneration process helps maintain a robust defense system against oxidative stress