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Data from a large retrospective cohort study to be presented at the 2026 American Society of Clinical Oncology (ASCO) Breakthrough Meeting showed that GLP-1 receptor agonist (GLP-1 RA) use was significantly associated with lower colorectal cancer incidence among patients with inflammatory bowel disease (IBD), including those with comorbid type 2 diabetes (T2D)
RNA sequencing analyses have confirmed GLP-1R gene expression in EAT, and immunofluorescence studies have further validated the presence of GLP-1R protein, whereas no such signal has been detected in subcutaneous fat (95)
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