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It is also important to monitor for interactions with over-the-counter medications and herbal supplements, as these can also affect the metabolism of lamotrigine

Recent studies have also suggested serum metabolites are altered in endometriosis 16 , that genetic/epigenetic changes caused by retrograde menstruation into the peritoneal cavity contribute to lesion development (reviewed in 17 ), and that genetic pre-disposition may differ in relation to ethnicity 18

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Different modes of administration such as oral administration, intravenous injection and topical application affect the bioavailability and therapeutic efficacy of drugs.Wang H