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nder C, Kurgan , Altngz SM, Ba N, Uyank M, Serdar MA, Kantarc A, Gnhan M
J.PerssonF.RosenlundS.HovindP.FaberJ.HansenT
In a randomized, double-blind, placebo-controlled trial involving 100 children with severe obesity (612 years), alongside lifestyle interventions conducted for 6 months, the metformin group showed a greater reduction in BMI (difference between metformin and placebo groups 1.09 0.38 kg/m 2 , p = 0.006) and BMI z-score (difference between metformin and placebo groups 0.07 0.03, p = 0.02) [42]
The ambivalence of clinical results may be closely related to several factors: (1) differences in patient staging, as positive trials predominantly included patients with early-stage PD, while negative trials encompassed a broader range of disease stages, where neuronal damage may have become irreversible in late-stage patients (Yoritaka et al., 2018)
