Additionally, melatonin significantly reduced the number of NFTs and attenuated neuronal loss in the cortex and hippocampus [115]
Benzyl alcohol toxicity in neonates was documented in published case series and FDA communications beginning in the early 1980s, describing a syndrome characterised by metabolic acidosis, gasping respirations, CNS depression, and in some cases death now referred to as 'gasping syndrome.' Neonates lack the hepatic enzyme capacity to metabolise benzyl alcohol effectively, leading to toxic accumulation of benzoic acid
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Therefore, to eliminate the potential baseline effect of different studies, the rates of body weight change from the initial values were selected as the therapeutic index, which was a better indicator used to assess changes in body weight
