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Crucially, in all three cell lines, the de novo GSH synthesis inhibitor buthionine sulfoximine (BSO) abolished the ability of MPA and Pyr pretreatment to inhibit ferroptosis, consistent with a GSH-dependent protective mechanism (Fig 4B)

They give the body the instructions it needs to repair, rebalance, and regenerate

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Chemotherapy rescues hypoxic tumor cells and induces their reoxygenation and repopulation - an effect that is inhibited by the hypoxia-activated prodrug TH-302

While p16 ink4a and SA--Gal are widely used in aging studies, emerging evidence suggests that p21 (a cyclin-dependent kinase inhibitor) may be a more robust marker of senescence in human kidney disease, particularly in contexts of chronic injury and fibrosis (Knoppert et al., 2023