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A 2016 review of 2 randomized clinical trials and 3 prospective studies concluded that oral B12 at 1,000 mcg a day was a safe and effective alternative to intramuscular injections

Common adverse effects include nausea, vomiting, and diarrhoea

Despite lower bioavailability, clinical trials demonstrate meaningful glycemic and weight outcomes in real-world settings

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Therefore, we speculated that T cells could induce microglial polarization through direct contact, cytokine-mediated communication or antigen presentation, thereby amplifying their impact on the cerebral immune milieu

An insulin stain was performed on adjacent sections to ascertain that the islets were healthy (Fig