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Systemic perturbation of the circadian clock in different transgenic mouse models resulted in a partial loss of blood pressure control (8), substantial changes in the circadian pattern of urinary water, sodium and potassium excretion (9), and accelerated progression of CKD (10)

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A normal dose is up to 1,000 milligrams (mg) over a four-to-six-hour period and a total of no more than 4,000 mg in a day