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| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data
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Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence