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Compounded semaglutide: Typical concentration: 2.5 mg/mL or 5 mg/mL Supplied as lyophilized powder requiring reconstitution with bacteriostatic water, or as pre-mixed solution Dosing follows the same titration schedule as Wegovy (0.25 mg to 2.4 mg weekly) Often includes cyanocobalamin (B12) as a co-ingredient, though this is not required Cost: $250 to $400 per month depending on dose and pharmacy Compounded tirzepatide: Typical concentration: 5 mg/mL or 10 mg/mL Supplied as lyophilized powder requiring reconstitution, or as pre-mixed solution Dosing follows the same titration schedule as Zepbound (2.5 mg to 15 mg weekly) Some formulations include B12 or other additives Cost: $350 to $500 per month depending on dose and pharmacy Important distinctions: Compounded medications are not FDA-approved and have not undergone the same testing as brand-name drugs Potency, sterility, and stability are the responsibility of the compounding pharmacy, not the FDA Compounded versions are not interchangeable with brand-name products Insurance does not cover compounded GLP-1 medications in most cases The quality of compounded semaglutide and tirzepatide varies by pharmacy

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MRPA-independent mechanisms of antimony resistance in Leishmania infantum