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The reduced flux through the oxidative phosphorylation pathway also carries forward to the electron transport chain at the inner mitochondrial membrane

The brains and other major organs were harvested, weighed, and solubilized using aqua regia

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showed that ARID1A-deficient cancer cells expressed low levels of the key cystine transporter SLC7A11 and thus exhibited low basal levels of GSH, which made these cancer cells specifically vulnerable to inhibition of the GSH metabolic pathway 25

Stress Biol 1(1):2