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We recently developed a series of feeding regimens that enabled us to dissect the relative contribution of fasting from energy restriction in the CR diet paradigm

Incorrect methods can lead to a less effective or even unsafe product

10.1146/annurev-animal-022114-110829 146 MizutaniK.IkedaK.KawaiY.YamoriY

The average value of CRP prior to the intervention, at T=0, was very high, 9 times more than the normal range

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doi: 10.1016/j.neuroscience.2011.02.031