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Davies, M

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Advances in mechanistic understanding have revealed a multifactorial pathogenesis, characterised by dysregulated inflammation, disruption of the gut-liver axis, oxidative stress, impaired regeneration, and genetic susceptibility, each of which offers rational targets for intervention

In a recent cohort study that included 11,222 healthy subjects with no carotid plaques at baseline, 25.94% of subjects (1,071 women and 1,840 men) developed carotid artery plaques over 10 years

In the SURMOUNT-1 trial, 2539 people with overweight (body mass index (BMI) 27 kg/m 2 and one obesity related complication) and obesity BMI 30 kg/m 2 were treated with tirzepatide 5, 10, or 15 mg or placebo for 72 weeks

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