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The trade-off is more injections per session and more reconstitution math

In a third case of MNTI, the patient was followed up after initial therapy for two decades and underwent multiple reconstruction procedures to achieve successful rehabilitation

The key distinction: type 2 GLP-1 use targets insulin resistance and beta-cell dysfunction, whereas type 1 use focuses on glycemic stability, weight management, and cardiovascular protection alongside mandatory insulin

In SURPASS-2, which compared tirzepatide to semaglutide 1 mg in 1,879 patients with type 2 diabetes, tirzepatide 5 mg, 10 mg, and 15 mg reduced systolic blood pressure from baseline by 5.6, 7.4, and 8.0 mmHg respectively at 40 weeks, compared to 5.3 mmHg with semaglutide