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Other Potential Effects Acromegaly-like effects from chronic IGF-1 elevation could theoretically include jaw enlargement, soft tissue growth, carpal tunnel syndrome, joint pain, and organ enlargement, though these typically require prolonged excessive elevation

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Although initial studies suggested that GSH depletion was only a byproduct of oxidative stress generated during cell death, recent discoveries suggest that GSH depletion and post-translational modifications of proteins through glutathionylation are critical regulators of apoptosis