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revealed that upregulated PDK1 activates epidermal growth factor receptor (EGFR) to facilitate the development of chemotherapy resistance (37)

Nonetheless, as -cells become exhausted in the later stages of the disease, amylin secretion diminishes [23,25]

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Ethanol is oxidized to acetaldehyde by alcohol dehydrogenase I (ADH1), catalase (CAT) and/or cytochrome P450 2E1 (CYP2E1)

Looking forward, continued progress in nanomaterial design and synthesis, coupled with deeper insights into oral cancer pathophysiology, is expected to yield more efficient, safer, and highly precise nanoscale DDSs

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