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Primarily, it boosts muscle strength and mass by binding to the IGF-1 receptor on muscle cells via the PI3K/Akt/mTOR and PI3K/Akt/GSK3 pathways

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Poor sleep increases ghrelin (hunger hormone) levels and reduces the appetite-suppressing effects of GLP-1 receptor activation

When pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) stimulate the activation of the NF-B signaling pathway, inflammasomes assemble

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And direct GLP-1 receptor activation in neurons appears to modulate microglial activity, dampening the chronic immune response that underlies much late-life cognitive decline