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Plants such as bracken ferns are problematic while toxicity symptoms vary widely based on dose, duration, and species of affected animals these plants contain thiaminases, and thiamine deficiency has been noted in sheep grazing on the plants in Australia

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They are commonly included in longevity and performance optimization protocols

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These studies indicate that 5-amino-1mq can delay skin fibroblast senescence by regulating NAD+ metabolism, providing a novel intervention target for skin anti-aging research