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In animal studies, resmetirom increases the expression of genes involved in fatty acid oxidation ( CPT1A , ACOX1 ), mitochondrial biogenesis ( PPARGC1A ), and cholesterol catabolism ( CYP7A1 ), while reducing levels of lipogenic targets ( SREBP-1c , FASN ) [1921]
doi:10.1007/s00394-023-03241-6
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Potential CNS access: The nose-to-brain pathway makes intranasal delivery especially interesting for neurological and cognitive applications
Tropolone, another tyrosinase inhibitor that has been studied, was also found at the entrance of the active site of mushroom tyrosinase and exhibited mixed inhibition mode similar to KA 41,42
Finally, the reliance upon fresh peripheral blood mononuclear cells (PBMCs), which we and others have shown to be optimal for MAPPs sensitivity 16 , brings a degree of randomness and difficulty to sample alleles from different geographies that reflect the span of HLA-DRB1 alleles present in diverse patient populations
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