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A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

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4a show that HFD feeding induced higher fasting glucose levels compared to that of animals fed a regular chow, and exhibited a much slower clearance rate of injected glucose

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