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Longitudinal analysis of impulse control disorders in Parkinson disease

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Increased tissue IGF-1R mRNA levels strongly correlate with poor patient clinical outcomes across different molecular BrCa subtypes [73], whereas IGF-1R is highly expressed in patients with early BrCa and overall positively associated with good prognostic variables

Both of these enzyme deficiencies are typically discovered during childhood and were therefore initially described in pediatric literature [2]

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