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Under cholesterol stimulation, EX-4 and AICAR increased the ratio of p-AMPK/AMPK, ABCA1 protein levels, and cell viability, which were further promoted by their co-treatment (Figures 2B,C)

Mean SD (n = 5 biological replicates)

Data ( b, d, f ) are shown as box-and-whisker plots: boxes indicate the 25th75th percentiles, central lines indicate medians, and whiskers indicate minimum to maximum values

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Structural and biochemical analyses reveal the mechanism of glutathione S-transferase Pi 1 inhibition by the anti-cancer compound piperlongumine

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