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Current clinical studies use a weekly schedule, with dose increases over time to support tolerability

Patients included in the trial had diabetes and fulfilled the following criteria for kidney disease at the time of randomization: a urinary albumin-to-creatinine ratio (UACR) of 30300 (mg/g), estimated glomerular filtration rate (eGFR) of 2560 (ml/min/1.73m 2 ), or a UACR of 3005000 and eGFR of 2575 (ml/min/1.73m 2 ) along with diabetic retinopathy (see 17 for further details)

The investigators identified adults with CKD stage 3 or later and T2DM who were newly prescribed either a GLP-1RA or a dipeptidyl peptidase-4 inhibitor (DPP4i) between January 2015 and December 2020

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