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The combination of BMS-704807 and U0126 efficiently suppresses the growth and induces cell death in colon tumor cells Our results suggested that activation of MEK1/2 is a key event for the induction of p70S6K1 phosphorylation in resistance to IGF-1R inhibition

Its tertiary amine structure facilitates penetration across the bloodbrain barrier, enabling central nervous system (CNS) effects via interaction with central muscarinic receptors

It was further shown that in some cases, including a large percentage of human non-small cell lung cancers, AKT activity can be low despite loss of PTEN

Chem Phys Lipids (2008) 153:4756

Epub 2015 Jul 24 7

The honest answer is: not convincingly