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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

In the future, the use of synthetic biology technology to introduce MOTS-c into probiotics to achieve its accurate and controllable expression is of great significance to human health and the prevention of various diseases ( Figure 2 )

Due to the N-terminal truncation, PYY (3-36) shows high selectivity and affinity for Y2 receptors (45), retaining part of the activity on Y5 receptors (46), but the binding ability to Y1 and Y4 receptors is greatly reduced (47)

The combination can amplify hypoglycemia risk (dangerously low blood sugar) or cause wide fluctuations between highs and lows

doi:10.37349/eds.2024.00069

GLP-1 and GIP both influence metabolic signaling, appetite regulation, insulin response, and energy balance