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Based on evidence from the Semaglutide Treatment Effect in People with Obesity (STEP) 1 randomised controlled trial, the guidance recommends that semaglutide should be considered in adults with at least one weight-related condition and a body mass index (BMI) of at least 35

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Your gut releases it when food shows up, and it does two things researchers care about: it tells your brain you're full, and it slows how fast your stomach empties